Manchester United will again be without Eric Bailly and Phil Jones as Brighton arrive in Saturday's Premier League encounter.
Marcos Rojo played the entirety of the midweek Champions League trip to Basel after 216 days out following a serious knee injury and the defender's match fitness will be assessed ahead of Saturday.
Zlatan Ibrahimovic is not yet ready to start, while captain Michael Carrick remains sidelined. Ashley Young, Juan Mata and Antonio Valencia did not travel to Wednesday's Champions League clash at Basel.
Jose Mourinho said: "I prefer him [Zlatan] on the pitch than off the pitch. On the pitch, he’s another option for us and he’s an option of quality. His physicality and his intelligence, the way he moves, the way he plays.
"But he needs time. We managed to give him 15/20 minutes in both matches, he needs more of that, so hopefully, tomorrow, we play him again.
"Paul is still on this process where he cannot reach the fatigue limit," explained the boss. "He cannot go more than 65 to 70 minutes because that’s when fatigue normally arrives and, with so many matches consecutively, we need to protect such an important player for us."
Provisional squad: De Gea, Romero, Pereira, Valencia, Young, Tuanzebe, Darmian, Lindelof, Rojo, Smalling, Shaw, Blind, Pogba, McTominay, Matic, Herrera, Fellaini, Lingard, Mata, Mkhitaryan, Rashford, Ibrahimovic, Lukaku, Martial.