Only goalkeeper Petr Cech keeps his place in Wenger's starting XI from Arsenal's Europa League win over Red Star Belgrade in midweek.
Gunners fans will be excited to see Alexis Sanchez, Mesut Ozil and Alexandre Lacazette form the frontline - the first time since the latter's arrival in the summer.
While Ronald Koeman has welcomed back Michael Keane, Phil Jagielka and Leighton Baines after resting the trio in the midweek Europa League defeat to Lyon.
Everton: Pickford, Kenny, Keane, Jagielka, Williams, Baines, Gueye, Vlasic, Sigurdsson, Rooney, Calvert-Lewin
Subs: Joel, Mirallas, Martina, Niasse, Klaassen, Davies, Lookman
Arsenal: Cech, Koscielny, Mertesacker, Monreal, Ramsey, Xhaka, Bellerin, Kolasinac, Ozil, Sanchez, Lacazette
Subs: Macey, Holding, Coquelin, Wilshere, Iwobi, Walcott, Giroud
*** FOLLOW ALL THE ACTION AT GOODISON PARK IN OUR EVERTON VS ARSENAL LIVE BLOG ***