With a lot of teams in Champions League and Europa League action, attention turns back to the top flight.
Chelsea welcoming City is undoubtedly the highlight of the weekend with Antonio Conte and Pep Guardiola determined to come away from Stamford Bridge with all three points.
Speaking to Sky Sports, Merson explained how he thinks United could capitalise if they can see off Palace at Old Trafford at 3pm on Saturday.
Tottenham start the weekend action off when they travel to Huddersfield, while Liverpool are last in action against Newcastle.
Arsenal face Brighton, Everton host Burnley and Stoke welcome Southampton.
United and City currently top the table level on 16 points at this early stage.
CHECK OUT ALL OF MERSON'S PREDICTION IN THE GALLERY ABOVE
