Manchester United vs Southampton: Team news, kick-off time, likely line-ups, odds and stats from the Premier League clash

• e-mail

Ahead of this weekend's Premier League action, Sportsmail will be providing you with all you need to know about every fixture, with team news, provisional squads, betting odds and Opta stats. Here is all the information you need for Manchester United's clash with Southampton at 17:30pm on Saturday at Old Trafford.

In or out? Keep up-to-date with the latest team news and stats ahead of the weekend's action

Manchester United vs Southampton (Old Trafford) 

Team News

Manchester United 

Romelu Lukaku looks set to retain his place in Manchester United's team against Southampton, despite Jose Mourinho insisting he is jaded.

Mourinho said his striker, who has played every single minute of United's 20 Premier League games, is "tired" having scored just four times in 19 games yet feels he cannot give him a rest.

Anthony Martial and Matteo Darmian both returned to training on Thursday but remain doubtful with the knocks that kept them out against Burnley, while Chris Smalling and Antonio Valencia are also unlikely to feature. Michael Carrick, Marouane Fellaini and Eric Bailly are all out.

Provisional squad: De Gea, Romero, Pereira, Tuanzebe, Darmian, Jones, Smalling, Lindelof, Young, Rojo, Shaw, Blind, McTominay, Pogba, Herrera, Matic, Lingard, Martial, Rashford, Mata, Mkhitaryan, Lukaku, Ibrahimovic.

Romelu Lukaku will retain his place up front despite boss Jose Mourinho saying he looks jaded

Southampton 

Southampton defender Virgil van Dijk will join Liverpool on January 1, so will not feature in Saturday's Premier League clash with Manchester United.

Charlie Austin is unavailable as he must serve the second of his three-match ban for violent conduct and the forward is also affected by a significant hamstring injury.

Ryan Bertrand (hamstring) faces a late fitness test, but Cedric Soares (ankle) will not feature for Mauricio Pellegrino's side.

Southampton will be without Liverpool bound Virgil van Dijk for the trip to Manchester United

Manchester United vs Southampton key match stats

Supplied by Opta 

The Red Devils have kept a clean sheet in each of their last three Premier League games against Southampton, after a run of nine games without one.

Southampton have won two of their last three league visits to Old Trafford, after a run of 19 games without a win there (D3 L16). Indeed, their last two away wins against Man Utd came over a period of 35 games.

Manchester United won the reverse fixture thanks to a Romelu Lukaku goal – they’ve not beaten Southampton home and away in the same season since 2012-13.

Southampton have won just one of their last 11 Premier League games (D4 L6) and none of the last seven. Indeed, Saints have failed to keep a clean sheet in each of those 11 matches.

Mauricio Pellegrino has won just 20% of his 20 Premier League games in charge of Southampton (W4 D7 L9) – the third worst win rate by a Saints manager in the competition behind Harry Redknapp (18.2%) and Steve Wigley (6.2%).

Zlatan Ibrahimovic has netted an impressive four times in two games against Southampton

Man Utd have lost just two of their 29 Premier League home games under Jose Mourinho (W16 D11 L2), with both defeats coming at the hands of Man City.

Man Utd find themselves 15 points behind rivals Man City – the biggest points gap between first and second place after 20 games in English top-flight history.

Man Utd have scored nine goals via substitutes in the Premier League this season – one more than in the previous two seasons combined (8).

Zlatan Ibrahimovic has scored four goals in his two games against Southampton in all competitions.

Jesse Lingard has had a hand in 10 Premier League goals this season (6 goals, 4 assists in 16 apps) – more than in his previous three seasons combined (5 goals, 3 assists in 51 games).