Liverpool deepened West Ham United's problems as they strolled to a 4-1 win at the London Stadium.
West Ham came close to taking the lead with 10 minutes gone when Andre Ayew hit the outside of the post, but the home side conceded two goals in three minutes as the visitors took control.
Ten minutes into the second half, a lovely piece of control from Manuel Lanzini allowed him to lift a finish past Mignolet -- only for Liverpool to get their two-goal lead back within a minute through Alex Oxlade-Chamberlain.
Lanzini blazed over when he should have made it 3-2 but with 15 minutes left Liverpool made it four when Salah, given far too much space inside the West Ham box, thrashed a low shot into the corner.
Burnley won 1-0 at Southampton to move up to sixth in the Premier League as their excellent season continued.
The visitors had the first attempt of the afternoon when Johann Berg Gudmundsson fired wide, but chances were few and far between in a tight first half an hour.
Burnley were grateful to keeper Nick Pope, who pushed away Sofiane Boufal's volley, and Pope made another good stop to deny Maya Yoshida early in the second half.
The value of those saves became apparent with nine minutes remaining when Sam Vokes headed home Gudmundsson's excellent cross to give the visitors the points.
Brighton moved into the top half of the table and deepened Swansea's concerns with a 1-0 win at the Liberty Stadium.
Chris Hughton's visitors had the better of the early moments and home keeper Lukasz Fabianski had to tip an attempted cross from Jose Izquierdo over the bar.
They came close again when Pascal Gross saw an effort deflect past Fabianski but wide of the post, but with 29 minutes gone they broke through when Anthony Knockaert set up Glenn Murray for his fourth goal in three games.
Brighton keeper Matt Ryan kept his side's lead intact when Nathan Dyer set up Tammy Abraham -- but that was a rarer moment of intent from Swansea, who could have gone 2-0 down when Solly March was crowded out after breaking through.
Peter Crouch's second-half header earned Stoke a point at home to Leicester and ensured a familiar scoreline at the bet365 Stadium.
It was the third season in a row that the two teams have drawn 2-2 in this fixture, with substitute Crouch pegging back Leicester for the second time after Xherdan Shaqiri had equalised in the first half.
Vicente Iborra's first goal in English football had given Leicester a deserved lead, which Riyad Mahrez restored on the hour mark, but Crouch salvaged a point and nearly when his late header was saved by Kasper Schmeichel.
Bournemouth grabbed an injury-time winner to triumph 1-0 at Newcastle and lift themselves out of the Premier League relegation zone.
Newcastle dominated the opening stages and thought they had taken the lead after 18 minutes when ex-Bournemouth player Matt Ritchie hit the post and Dwight Gayle was adjudged offside when turning in the rebound.
But Bournemouth worked their way back as the first half came to an end and Rob Elliot had to make a sharp stop from a looping Callum Wilson header.
They should have led in the opening stages of the second half when Wilson shot wide with only the goalkeeper to beat, and looked to have been frustrated when Marc Pugh hit the inside of the post -- but Steve Cook rose to head home a corner with seconds left on the clock.
Huddersfield survived the sending off of Christopher Schindler to beat West Bromwich Albion 1-0 at the John Smith's Stadium.
The home side wanted a penalty just after the quarter-hour mark when Scott Malone made a sliding challenge on Rajiv van La Parra, but the referee waved appeals away.
West Brom hit back and the home side were grateful for a good block by Florent Hadergjonaj from Jay Rodriguez but Huddersfield had -- and missed -- a good chance when Tom Ince blasted over from inside the box.
With half-time looming, the home side took the lead when Van La Parra curled home an outstanding finish from 25 yards -- but although they went down to 10 men after 57 minutes when Schindler got a second yellow, they staved off a late West Brom flurry thanks to two excellent late saves from keeper Jonas Lossl.