Jose Mourinho is expected to make multiple changes for Manchester United's trip to Bristol City.
United take on the Championship high-flyers in the Carabao Cup quarter-final at Ashton Gate on Wednesday night.
The Red Devils beat West Brom on Sunday and Mourinho is likely to rotate his squad with a hectic festive fixture programme coming up.
Paul Pogba is set to return after his ban while Zlatan Ibrahimovic could be handed his first start since returning from his long-term injury lay-off.
The likes of Sergio Romero, Victor Lindelof and Scott McTominay, who started on the bench at the Hawthorns could all come in.
Henrikh Mkhitaryan, whose future appears bleak after another snub, could return to the fold.
Meanwhile, United boss Jose Mourinho admits he must wait to discover the severity of Antonio Valencia's injury.
The skipper limped off with a hamstring problem during Sunday's 2-1 win
Mourinho said: "The Valencia injury is what I call a December injury. It is an injury of the accumulation of fatigue. It is a muscular one - hamstring, big small, medium? I don't know.
"He is an experienced guy to not let it go to difficult limits. But it is an injury of fatigue - everyone in the Premier League, especially the ones with more accumulation of cups and European cups - are at risk."
Valencia now joins Eric Bailly on the sidelines with the centre-back ready to undergo surgery on his injured ankle which could sideline him for three months.