Liverpool have confirmed the appointment
The former Doncaster Rovers boss has come to an agreement with The FA to leave his role as England under-19 coach, and replaces Colin Pascoe as Brendan Rodgers' number two.
And Rodgers is delighted to have secured the services of such a highly-regarded coach.
"I have made these appointments because I want to take us in a new technical direction, in terms of coaching," he told the club's official website.
"I believe the entire first-team set-up will benefit and I am extremely positive and excited about what we can achieve, as a group, going forward.
"My admiration for Sean, as a professional, is well documented
"He is someone with a clear vision and philosophy and has proved he has the ability to transfer that knowledge, through his coaching, to the players.
"I am looking forward to working with him and also learning from his experiences and gaining valuable knowledge from his expertise."
Academy coach Pepijn Lijnders will also be stepping up to join the first-team backroom staff but academy director Alex Inglethorpe, linked to the role, has no desire to leave his current post and will remain in charge of the club's youth ranks.
and
were both candidates to replace Pascoe but were overlooked in favour of O'Driscoll.
Hyypia may be given an opportunity to return at Anfield as a replacement for departed first-team coach Mike Marsh, but is understood to prefer a more senior position or return to management elsewhere.
What do fans of his former clubs think of Sean O'Driscoll? We asked them...