Arsene Wenger has changed Arsenal's formation for their trip to Manchester City in a bid to blunt the Blues' deadly forward line.
The Frenchman has reverted to four at the back instead of the three centre-halves he has used in recent weeks.
Nacho Monreal will be deployed in the centre of defence alongside Laurent Koscielny, flanked by Hector Bellerin and Sead Kolasinac.
Wenger will play a 4-3-3 with Aaron Ramsey, Granit Xhaka and Francis Coquelin sitting behind Mesut Ozil, Alexis Sanchez and Alex Iwobi.
Pep Guardiola has again selected an array of attacking talent with Kevin De Bruyne, David Silva, Raheem Sterling, Leroy Sane and Sergio Aguero all starting.
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Manchester City: Ederson, Walker, Stones, Otamendi, Delph, Fernandinho, Silva, De Bruyne, Sane, Sterling, Aguero
Subs: Bravo, Danilo, Gundogan, Mangala, Bernardo, Jesus, Yaya Toure
Arsenal: Cech, Bellerin, Koscielny, Monreal, Kolasinac, Xhaka Coquelin, Ramsey, Ozil, Iwobi, Sanchez
Subs: Debuchy, Lacazette, Wilshere, Giroud, Walcott, Elneny, Macey