Premier League weekend preview: Manchester City vs Manchester United, Newcastle vs Liverpool and all the major talking points

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Each week, The Independent will look ahead to the weekend's action in the Premier League with a video detailing the five key things to watch out for during the matches.

The Independent's online sports writers once again discuss all of the major match-ups and talking points set to dominate this weekend's Premier League agenda.

This week, Simon Rice and Jack de Menezes look ahead to the massive north-west derby between city rivals Manchester City and Manchester United. It was City that came away with the bragging rights last season, with the Premier League Champions winning 4-1 at the Etihad and 3-0 at Old Trafford respectively.

Nevertheless, with captain Wayne Rooney and Colombian striker Radamel Falcao both set to return from injury, United will be confident that they can avenge last season's embarrassments.

Other games see Arsenal come up against a Burnley at the Emirates. The Lancashire club have not won a competitive match since 26 April and it looks like they will have to wait even longer for that elusive victory against an Arsenal side that are aiming to string together their first back-to-back wins this season.

The weekend might also spell the end of Gus Poyet's tenure as manager of Sunderland. After picking up only one win in the league this season and with the 8-0 defeat at Southampton still fresh, the Uruguyan has come under increased pressure of late. A win against Crystal Palace on Saturday will be imperative if the man who did so well to keep the Black Cats up last season wants to remain in charge at the Stadium of Light.