The Everton defender, one of five senior internationals in the squad, missed the opening matches with Portugal and Sweden with suspected concussion, but is available to start at the Ander Stadium.
Liam Moore makes way against the Azzurrini, while Jake Forster-Caskey, Jesse Lingard and Danny Ings replace Tom Carroll, Alex Pritchard and Will Hughes.
England: Butland (c), Jenkinson, Garbutt, Forster-Caskey, Stones, Gibson, Kane, Redmond, Chalobah, Ings, Lingard
Subs: Ward-Prowse, Carroll, Bond, Bettinelli, Keane, Hughes, Afobe, Moore, Chambers, Targett, Loftus-Cheek
Italy: Bardi; Zappacosta, Rugani, Romagnoli, Biraghi; Crisetig, Benassi, Cataldi; Berrardi, Trotta, Belotti
